(1988), Biochemistry
Graduate School
University of Basel (1988), Biology
Graduate School
University of Basel (1992), Biochemistry

Research Interest

  • Adipose Tissue
  • Interorgan Hormonal Crosstalk
  • Lipid Messengers
  • Obesity and Cancer
  • Obesity and Diabetes


Featured Publications LegendFeatured Publications

Why does obesity cause diabetes?
Klein S, Gastaldelli A, Yki-Järvinen H, Scherer PE, Cell Metab 2022 Jan 34 1 11-20
Response to Kunos et al. and Lotersztajn and Mallat.
Wang S, Zhu Q, Liang G, Franks T, Boucher M, Bence KK, Lu M, Castorena CM, Zhao S, Elmquist JK, Scherer PE, Horton JD, J Clin Invest 2022 Jan 132 1
The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease.
Colca JR, Scherer PE, Mol Metab 2021 Dec 55 101409
Mitochondrial regulation and white adipose tissue homeostasis.
Zhu Q, An YA, Scherer PE, Trends Cell Biol 2021 Nov
Skin aging: Dermal adipocytes metabolically reprogram dermal fibroblasts.
Kruglikov IL, Zhang Z, Scherer PE, Bioessays 2021 Nov e2100207
Obesity, Diabetes, and Increased Cancer Progression.
Kim DS, Scherer PE, Diabetes Metab J 2021 Nov 45 6 799-812
Integrated Stress Response Couples Mitochondrial Protein Translation with Oxidative Stress Control.
Zhang G, Wang X, Li C, Li Q, An YA, Luo X, Deng Y, Gillette TG, Scherer PE, Wang ZV, Circulation 2021 Sep
Cannabinoid receptor-1 signaling in hepatocytes and stellate cells does not contribute to NAFLD.
Wang S, Zhu Q, Liang G, Franks T, Boucher M, Bence KK, Lu M, Castorena CM, Zhao S, Elmquist JK, Scherer PE, Horton JD, J Clin Invest 2021 Sep
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes.
Crewe C, Funcke JB, Li S, Joffin N, Gliniak CM, Ghaben AL, An YA, Sadek HA, Gordillo R, Akgul Y, Chen S, Samovski D, Fischer-Posovszky P, Kusminski CM, Klein S, Scherer PE, Cell Metab 2021 Aug
Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis.
Zhu Y, Li N, Huang M, Bartels M, Dogné S, Zhao S, Chen X, Crewe C, Straub L, Vishvanath L, Zhang Z, Shao M, Yang Y, Gliniak CM, Gordillo R, Smith GI, Holland WL, Gupta RK, Dong B, Caron N, Xu Y, Akgul Y, Klein S, Scherer PE, Nat Commun 2021 08 12 1 4829

Honors & Awards

  • Transatlantic Medal 2022
    Society for Endocrinology (United Kingdom) (2022)
  • Basic and Translational Science Award
    International Diabetes Federation (IDF) (2019)
  • Manpei Suzuki International Prize for Diabetes Research
    Japanese Diabetes Prize (2018)
  • The Gerald M. Reaven Distinguished Leader in Insulin Resistance Award
    WCIRDC (2018)
  • Novo Nordisk Found Diabetes Prize for Excellence
    Eur. Assoc. for the Study of Diabetes (EASD) (2017)
  • Banting Medal
    American Diabetes Association (2015)
  • Naomi Berrie Award for Outstanding Achievement in Diabetes Research
    Columbia University (2013)
  • J. Dennis McGarry Award for Outstanding Healthcare Professional
    American Diabetes Association, North Texas (2012)
  • O’Donnell Award in Medicine
    TAMEST (The Academy of Medicine, Engin. & Science of Texas) (2012)
  • Vladimir Nigrovic Award of Excellence
    University of Toledo (2009)
  • Texas Stars Award
    University of Texas (2007)
  • Outstanding Scientific Achievement Award
    Lilly Award - American Diabetes Association (2005)
  • Irma T. Hirschl/Monique Weill-Caulier Trust Research Award

Professional Associations/Affiliations

  • American Diabetes Association
  • American Society for Biochemistry and Molecular Biology