Beatriz Fontoura, Ph.D.
Professor

EXPERIENCE

UT Southwestern, Department of Cell Biology, Professor (2012-present).

UT Southwestern, Department of Cell Biology, Associate Professor (2007-2012).

UT Southwestern, Department of Cell Biology, Assistant Professor (2005-2007).

University of Miami School of Medicine, Department of Molecular and Cellular Pharmacology, Assistant Professor (2001-2005).

Howard Hughes Medical Institute, Laboratory of Cell Biology, The Rockefeller University, New York, N.Y., Post-Doctoral Associate (1996-2001).

New York University School of Medicine, New York, N.Y., Department of Pathology, Graduate Student (PhD) (1991 - 1996).

Cornell University Medical College, New York, N.Y., Department of Physiology, Visiting Fellow (1988-1990).

Paulista School of Medicine, Sao Paulo, S.P., Brazil, Department of Biochemistry, Graduate Student (MS), (1985-1988).

University of Sao Paulo, Brazil, Biochemistry Laboratory, University Hospital, Staff Member (1984-1985).

Graduate School

New York University

Featured Publications

Aryl Sulfonamide Inhibits Entry and Replication of Diverse Influenza Viruses via the Hemagglutinin Protein.

White K, Esparza M, Liang J, Bhat P, Naidoo J, McGovern BL, Williams MAP, Alabi BR, Shay J, Niederstrasser H, Posner B, García-Sastre A, Ready J, Fontoura BMA, J Med Chem 2021 Jul

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression.

Zhang K, Miorin L, Makio T, Dehghan I, Gao S, Xie Y, Zhong H, Esparza M, Kehrer T, Kumar A, Hobman TC, Ptak C, Gao B, Minna JD, Chen Z, García-Sastre A, Ren Y, Wozniak RW, Fontoura BMA, Sci Adv 2021 Feb 7 6

Viral-induced alternative splicing of host genes promotes influenza replication.

Thompson MG, Dittmar M, Mallory MJ, Bhat P, Ferretti MB, Fontoura BM, Cherry S, Lynch KW, Elife 2020 12 9

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling.

Miorin L, Kehrer T, Sanchez-Aparicio MT, Zhang K, Cohen P, Patel RS, Cupic A, Makio T, Mei M, Moreno E, Danziger O, White KM, Rathnasinghe R, Uccellini M, Gao S, Aydillo T, Mena I, Yin X, Martin-Sancho L, Krogan NJ, Chanda SK, Schotsaert M, Wozniak RW, Ren Y, Rosenberg BR, Fontoura BMA, García-Sastre A, Proc Natl Acad Sci U S A 2020 11 117 45 28344-28354

Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway.

Aksenova V, Smith A, Lee H, Bhat P, Esnault C, Chen S, Iben J, Kaufhold R, Yau KC, Echeverria C, Fontoura B, Arnaoutov A, Dasso M, Nat Commun 2020 09 11 1 4577

Chemical intervention of influenza virus mRNA nuclear export.

Esparza M, Mor A, Niederstrasser H, White K, White A, Zhang K, Gao S, Wang J, Liang J, Sho S, Sakthivel R, Sathe AA, Xing C, Muñoz-Moreno R, Shay JW, García-Sastre A, Ready J, Posner B, Fontoura BMA, PLoS Pathog. 2020 Apr 16 4 e1008407

DEAD-box ATPases are global regulators of phase-separated organelles.

Hondele M, Sachdev R, Heinrich S, Wang J, Vallotton P, Fontoura BMA, Weis K, Nature 2019 Aug

Structural basis for influenza virus NS1 protein block of mRNA nuclear export.

Zhang K, Xie Y, Muñoz-Moreno R, Wang J, Zhang L, Esparza M, García-Sastre A, Fontoura BMA, Ren Y, Nat Microbiol 2019 Jul

Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination.

Liu Z, Yan M, Liang Y, Liu M, Zhang K, Shao D, Jiang R, Li L, Wang C, Nussenzveig DR, Zhang K, Chen S, Zhong C, Mo W, Fontoura BMA, Zhang L, Neuron 2019 Mar

Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.

Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, Kim M, Thompson MG, García-Sastre A, Lynch KW, Chen ZJ, Chook YM, Fontoura BMA Proc. Natl. Acad. Sci. U.S.A. 2018 Dec

• UM Sylvester Comprehensive Cancer Center Award
  (2004)
• Stanley J. Glaser Award
  (2002)
• UM Sylvester Comprehensive Cancer Center Award
  (2002)